Gene Therapy for Diabetic Retinopathy – Targeting the Renin-Angiotensin System
نویسندگان
چکیده
The prevalence of diabetes has been continuously increasing for the last few decades and it is being recognized as a worldwide epidemic [1]. Diabetic retinopathy (DR) is the most com‐ mon diabetic microvascular complication, and despite recent advances in therapeutics and management, DR remains the leading cause of severe vision loss in people under age of six‐ ty [2-4]. The prevalence of DR increases with duration of diabetes, and nearly all individuals with type 1 diabetes and more than 60% of those with type 2 have some form of retinopathy after 20 years [5-7].
منابع مشابه
Angiotensin‐converting enzyme gene variants interact with the renin–angiotensin system pathway to confer risk and protection against type 2 diabetic retinopathy
The angiotensin-converting enzyme (ACE) gene has been found to be associated with pathogenesis and progression of diabetic retinopathy (DR). A recent meta-analysis comprising 2,224 Chinese patients showed moderate evidence of a relationship between the ACE insertion/deletion (I/D) polymorphism and proliferative diabetic retinopathy (PDR); however, the role of other renin–angiotensin system (RAS...
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PURPOSE To determine if the renin-angiotensin system (RAS) is involved in diabetic retinopathy, we measured the levels of angiotensin-converting enzyme (ACE) and angiotensin II in the vitreous of patients with proliferative diabetic retinopathy (PDR). We also investigated whether the genes of the RAS factors were expressed by cultured human Müller cells. METHODS Vitreous samples were collecte...
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Many lines of evidence implicate the reninangiotensin system in the pathogenesis of diabetic retinopathy. A recent multicenter trial showed that angiotensin II type 1 (AT1) receptor blockade (ARB) reduced the incidence of retinopathy in type 1 diabetic patients and improved the regression of retinal disease in type 2 diabetic patients (1,2). However, the failure of ARB to prevent progression of...
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